:root {
  color-scheme: light;
  --ink: #17202a;
  --muted: #5b6472;
  --line: #d9e1ea;
  --surface: #ffffff;
  --paper: #f4f7fb;
  --cream: #fff8ed;
  --teal: #0f766e;
  --blue: #244f9e;
  --rust: #a54826;
  --gold: #b7791f;
  --green: #247044;
  --danger: #9d2433;
  --shadow: 0 18px 48px rgba(23, 32, 42, 0.1);
}

* {
  box-sizing: border-box;
}

body {
  margin: 0;
  min-height: 100vh;
  background:
    radial-gradient(circle at 16% 10%, rgba(15, 118, 110, 0.07), transparent 28rem),
    radial-gradient(circle at 84% 14%, rgba(36, 79, 158, 0.06), transparent 24rem),
    linear-gradient(180deg, #f8fafc 0%, var(--paper) 100%);
  color: var(--ink);
  font-family: Inter, ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
  letter-spacing: 0;
}

button,
input,
select {
  min-width: 0;
  font: inherit;
}

.topbar {
  display: grid;
  grid-template-columns: 1fr minmax(17rem, 28rem);
  gap: 1rem;
  align-items: end;
  width: min(1440px, calc(100% - 2rem));
  margin: 0 auto;
  padding: 1.25rem 0 0.9rem;
}

.topbar h1,
.section-heading h2 {
  margin: 0;
  letter-spacing: 0;
}

.topbar h1 {
  font-size: clamp(1.8rem, 3vw, 3rem);
  line-height: 1;
}

.dek {
  max-width: 44rem;
  margin: 0.55rem 0 0;
  color: var(--muted);
  font-size: clamp(0.98rem, 1.2vw, 1.08rem);
  line-height: 1.45;
}

.eyebrow {
  margin: 0 0 0.28rem;
  color: var(--teal);
  font-size: 0.76rem;
  font-weight: 750;
  letter-spacing: 0.08em;
  text-transform: uppercase;
}

.clinical-note {
  border-left: 4px solid var(--gold);
  background: rgba(255, 248, 237, 0.72);
  color: var(--muted);
  font-size: 0.95rem;
  line-height: 1.35;
  padding: 0.75rem 0.85rem 0.75rem 1rem;
}

.safety-banner {
  display: grid;
  grid-column: 1 / -1;
  grid-template-columns: minmax(16rem, 0.8fr) minmax(0, 1.4fr);
  gap: 1rem;
  align-items: start;
  border: 1px solid #ead8b7;
  border-left: 5px solid var(--gold);
  border-radius: 8px;
  background: var(--cream);
  box-shadow: 0 8px 24px rgba(183, 121, 31, 0.1);
  padding: 0.95rem 1rem;
}

.safety-banner h2 {
  margin: 0;
  font-size: 1.05rem;
  line-height: 1.25;
}

.safety-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 0.9rem;
}

.safety-grid p {
  margin: 0;
  color: #5e4931;
  font-size: 0.92rem;
  line-height: 1.45;
}

.workspace {
  display: grid;
  grid-template-columns: minmax(0, 0.88fr) minmax(0, 1.35fr);
  gap: 1rem;
  width: min(1440px, calc(100% - 2rem));
  margin: 0 auto;
  padding-bottom: 1rem;
}

.panel {
  min-width: 0;
  background: rgba(255, 255, 255, 0.94);
  border: 1px solid var(--line);
  border-radius: 8px;
  box-shadow: var(--shadow);
}

.input-panel,
.results-panel,
.sensitivity-panel,
.reference-panel {
  padding: 1rem;
}

.input-panel {
  align-self: start;
}

.results-panel {
  min-width: 0;
}

.sensitivity-panel,
.reference-panel {
  grid-column: 1 / -1;
  box-shadow: none;
}

.section-heading {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 0.75rem;
  margin-bottom: 0.9rem;
}

.section-heading h2 {
  font-size: 1.05rem;
  line-height: 1.2;
}

.icon-button {
  display: inline-grid;
  width: 2.35rem;
  height: 2.35rem;
  place-items: center;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #f9fbfd;
  color: var(--ink);
  cursor: pointer;
}

.icon-button:hover {
  border-color: #b9c7d6;
  background: #eef4fa;
}

.text-button {
  min-height: 2.35rem;
  border: 1px solid #c4ddd9;
  border-radius: 8px;
  background: #f1f8f7;
  color: var(--teal);
  cursor: pointer;
  font-size: 0.86rem;
  font-weight: 800;
  padding: 0 0.8rem;
}

.text-button:hover {
  border-color: #8dbdb5;
  background: #e6f3f1;
}

.hidden {
  display: none !important;
}

.mode-switch {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 0.65rem;
  margin-bottom: 1rem;
}

.mode-button {
  display: grid;
  gap: 0.25rem;
  min-height: 5.5rem;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fbfdff;
  color: var(--ink);
  cursor: pointer;
  padding: 0.8rem;
  text-align: left;
}

.mode-button.active {
  border-color: #8dbdb5;
  background: #f1f8f7;
  box-shadow: inset 0 0 0 2px rgba(15, 118, 110, 0.12);
}

.mode-button strong {
  font-size: 0.98rem;
}

.mode-button span {
  color: var(--muted);
  font-size: 0.86rem;
  line-height: 1.35;
}

.field-row,
.field {
  display: grid;
  align-content: start;
  gap: 0.45rem;
  min-width: 0;
}

.field-row {
  margin-bottom: 0.75rem;
}

.field-grid,
.maintenance-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(min(100%, 15.5rem), 1fr));
  gap: 0.9rem 0.8rem;
}

.maintenance-grid {
  grid-template-columns: repeat(3, minmax(0, 1fr));
  margin-bottom: 0.9rem;
}

label {
  display: inline-flex;
  align-items: center;
  flex-wrap: wrap;
  gap: 0.35rem;
  color: #344054;
  font-size: 0.86rem;
  font-weight: 700;
  line-height: 1.25;
}

.inline-help {
  margin: 0.2rem 0 0;
  color: var(--muted);
  font-size: 0.84rem;
  line-height: 1.35;
}

.help-tip {
  position: relative;
  display: inline-grid;
  flex: 0 0 auto;
  width: 1.05rem;
  height: 1.05rem;
  place-items: center;
  border: 1px solid #abcac5;
  border-radius: 999px;
  background: #f1f8f7;
  color: var(--teal);
  cursor: help;
  font-size: 0.72rem;
  font-weight: 900;
  line-height: 1;
  text-transform: none;
}

.help-tip::after {
  position: absolute;
  left: 50%;
  bottom: calc(100% + 0.55rem);
  z-index: 20;
  width: min(18rem, calc(100vw - 2rem));
  border: 1px solid #c7d6e2;
  border-radius: 8px;
  background: #ffffff;
  box-shadow: 0 14px 36px rgba(23, 32, 42, 0.16);
  color: var(--ink);
  content: attr(data-tip);
  font-size: 0.82rem;
  font-weight: 650;
  line-height: 1.35;
  opacity: 0;
  padding: 0.65rem 0.7rem;
  pointer-events: none;
  text-transform: none;
  transform: translate(-50%, 0.25rem);
  transition: opacity 0.14s ease, transform 0.14s ease;
}

.help-tip::before {
  position: absolute;
  left: 50%;
  bottom: calc(100% + 0.2rem);
  z-index: 21;
  width: 0.6rem;
  height: 0.6rem;
  border-right: 1px solid #c7d6e2;
  border-bottom: 1px solid #c7d6e2;
  background: #ffffff;
  content: "";
  opacity: 0;
  transform: translate(-50%, 0.25rem) rotate(45deg);
  transition: opacity 0.14s ease, transform 0.14s ease;
}

.help-tip:hover::after,
.help-tip:focus::after {
  opacity: 1;
  transform: translate(-50%, 0);
}

.help-tip:hover::before,
.help-tip:focus::before {
  opacity: 1;
  transform: translate(-50%, 0) rotate(45deg);
}

.compact-tip {
  margin-left: 0.25rem;
  vertical-align: middle;
}

select,
input[type="number"],
input[type="datetime-local"] {
  width: 100%;
  min-width: 0;
  min-height: 2.75rem;
  border: 1px solid #cbd7e3;
  border-radius: 8px;
  background: #fff;
  color: var(--ink);
  outline: none;
}

select {
  padding: 0 0.75rem;
}

input[type="number"] {
  padding: 0 0.65rem;
}

input[type="datetime-local"] {
  padding: 0 0.5rem;
}

select:focus,
input:focus {
  border-color: var(--teal);
  box-shadow: 0 0 0 3px rgba(15, 118, 110, 0.14);
}

.input-with-unit {
  display: grid;
  grid-template-columns: minmax(0, 1fr) auto;
  align-items: center;
  min-width: 0;
  overflow: hidden;
  border: 1px solid #cbd7e3;
  border-radius: 8px;
  background: #fff;
}

.input-with-unit:focus-within {
  border-color: var(--teal);
  box-shadow: 0 0 0 3px rgba(15, 118, 110, 0.14);
}

.input-with-unit input {
  border: 0;
  border-radius: 0;
  box-shadow: none;
}

.input-with-unit span {
  display: inline-flex;
  align-items: center;
  align-self: stretch;
  border-left: 1px solid var(--line);
  background: #f5f8fb;
  color: var(--muted);
  font-size: 0.84rem;
  font-weight: 700;
  padding: 0 0.65rem;
  white-space: nowrap;
}

.range-block {
  display: grid;
  gap: 0.5rem;
  margin-top: 0.9rem;
  border-top: 1px solid var(--line);
  padding-top: 0.9rem;
}

.range-labels,
.range-hints {
  display: flex;
  justify-content: space-between;
  gap: 1rem;
}

.range-hints {
  color: var(--muted);
  font-size: 0.82rem;
}

input[type="range"] {
  width: 100%;
  accent-color: var(--teal);
}

.assumption-box {
  margin-top: 0.9rem;
  border: 1px solid #d7e5e1;
  border-radius: 8px;
  background: #f4fbf9;
  color: #24524b;
  font-size: 0.9rem;
  line-height: 1.4;
  padding: 0.8rem;
}

.dose-card {
  margin-top: 0.95rem;
  border-top: 1px solid var(--line);
  padding-top: 0.9rem;
}

.section-heading.compact {
  margin-bottom: 0.55rem;
}

.dose-table {
  display: grid;
  gap: 0.6rem;
}

.dose-row {
  display: grid;
  grid-template-columns: minmax(12rem, 1.15fr) minmax(7rem, 0.7fr) minmax(10rem, 1fr) auto;
  gap: 0.55rem;
  align-items: end;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fbfdff;
  padding: 0.65rem;
}

.dose-row.simple {
  grid-template-columns: minmax(0, 1.2fr) minmax(5.75rem, 0.8fr) auto;
}

.shared-inputs {
  margin-top: 0.95rem;
  border-top: 1px solid var(--line);
  padding-top: 0.9rem;
}

.status-pill {
  border: 1px solid #cce2d5;
  border-radius: 999px;
  background: #f1faf5;
  color: var(--green);
  font-size: 0.78rem;
  font-weight: 800;
  padding: 0.28rem 0.6rem;
}

.result-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 0.75rem;
}

.range-card {
  display: grid;
  gap: 0.75rem;
  margin-bottom: 0.85rem;
  border: 1px solid #c4ddd9;
  border-radius: 8px;
  background: #f1f8f7;
  padding: 1rem;
}

.range-card strong {
  font-size: clamp(2rem, 4vw, 3.2rem);
  line-height: 1;
}

.range-line {
  display: grid;
  grid-template-columns: auto minmax(8rem, 1fr) auto;
  gap: 0.75rem;
  align-items: center;
  color: var(--muted);
  font-size: 0.9rem;
  font-weight: 800;
}

.range-track {
  position: relative;
  height: 0.6rem;
  border-radius: 999px;
  background: linear-gradient(90deg, #9fc7c1, #0f766e, #244f9e);
}

.range-track span {
  position: absolute;
  top: 50%;
  width: 1rem;
  height: 1rem;
  border: 2px solid #ffffff;
  border-radius: 999px;
  background: var(--ink);
  box-shadow: 0 2px 8px rgba(23, 32, 42, 0.28);
  transform: translate(-50%, -50%);
}

.range-card p {
  margin: 0;
  color: var(--muted);
  font-size: 0.92rem;
  line-height: 1.4;
}

.metric {
  display: grid;
  align-content: start;
  gap: 0.45rem;
  min-height: 8.25rem;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fbfdff;
  padding: 0.85rem;
}

.metric.primary {
  background: #f1f8f7;
  border-color: #c4ddd9;
}

.metric-label {
  display: inline-flex;
  align-items: center;
  flex-wrap: wrap;
  gap: 0.25rem;
  color: var(--muted);
  font-size: 0.78rem;
  font-weight: 800;
  text-transform: uppercase;
  letter-spacing: 0.06em;
}

.metric strong {
  display: block;
  min-width: 0;
  margin-top: 0.15rem;
  color: var(--ink);
  font-size: clamp(1.45rem, 2vw, 2.05rem);
  line-height: 1.12;
  overflow-wrap: anywhere;
}

.metric span:last-child {
  margin-top: 0;
  color: var(--muted);
  font-size: 0.86rem;
  line-height: 1.35;
  overflow-wrap: anywhere;
}

.chart-shell {
  margin-top: 0.9rem;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: linear-gradient(180deg, #ffffff 0%, #f8fbff 100%);
  padding: 0.65rem;
}

canvas {
  display: block;
  width: 100%;
  aspect-ratio: 2.25 / 1;
}

.formula-strip {
  margin-top: 0.8rem;
  border-left: 4px solid var(--blue);
  background: #f4f7fe;
  color: #273b64;
  font-size: 0.9rem;
  line-height: 1.45;
  padding: 0.75rem 0.85rem;
}

.table-wrap {
  max-width: 100%;
  overflow-x: auto;
}

table {
  width: 100%;
  min-width: 42rem;
  border-collapse: collapse;
  font-size: 0.94rem;
}

th,
td {
  border-bottom: 1px solid var(--line);
  padding: 0.8rem 0.75rem;
  text-align: left;
  white-space: nowrap;
}

th {
  color: var(--muted);
  font-size: 0.78rem;
  letter-spacing: 0.06em;
  text-transform: uppercase;
}

tbody tr:last-child td {
  border-bottom: 0;
}

.guardrail-grid {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 1rem;
}

.guardrail-grid h3 {
  margin: 0 0 0.4rem;
  font-size: 0.96rem;
}

.guardrail-grid p {
  margin: 0;
  color: var(--muted);
  font-size: 0.92rem;
  line-height: 1.45;
}

.references {
  display: flex;
  flex-wrap: wrap;
  gap: 0.55rem 1rem;
  margin: 1rem 0 0;
  padding: 0;
  list-style: none;
}

.references a {
  color: var(--blue);
  font-weight: 750;
  text-decoration-thickness: 0.08em;
  text-underline-offset: 0.16em;
}

.utility-panel {
  display: grid;
  grid-column: 1 / -1;
  grid-template-columns: minmax(18rem, 0.85fr) minmax(0, 1.35fr);
  gap: 1rem;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #ffffff;
  padding: 1rem;
}

.utility-panel h2 {
  margin: 0 0 0.5rem;
  font-size: 1.1rem;
  line-height: 1.25;
}

.utility-panel p {
  margin: 0;
  color: var(--muted);
  font-size: 0.94rem;
  line-height: 1.5;
}

.utility-grid {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 0.75rem;
}

.utility-grid div {
  display: grid;
  gap: 0.35rem;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fbfdff;
  padding: 0.85rem;
}

.utility-grid strong {
  font-size: 0.92rem;
}

.utility-grid span {
  color: var(--muted);
  font-size: 0.86rem;
  line-height: 1.4;
}

.site-footer {
  grid-column: 1 / -1;
  border-top: 1px solid var(--line);
  color: var(--muted);
  font-size: 0.82rem;
  line-height: 1.45;
  padding: 0.75rem 0.15rem 0.1rem;
}

.site-footer strong {
  display: block;
  margin-bottom: 0.25rem;
  color: #344054;
  font-size: 0.86rem;
}

.site-footer p {
  margin: 0;
}

.not-found-page {
  display: grid;
  min-height: 100vh;
  place-items: center;
}

.not-found-panel {
  max-width: 42rem;
  padding: 1.25rem;
}

.not-found-panel h1 {
  margin: 0 0 0.7rem;
  font-size: clamp(1.8rem, 3vw, 2.6rem);
}

.not-found-panel p:not(.eyebrow) {
  margin: 0 0 1rem;
  color: var(--muted);
  line-height: 1.5;
}

.text-link-button {
  display: inline-flex;
  min-height: 2.55rem;
  align-items: center;
  justify-content: center;
  border: 1px solid #c4ddd9;
  border-radius: 8px;
  background: #f1f8f7;
  color: var(--teal);
  font-weight: 800;
  padding: 0 0.9rem;
  text-decoration: none;
}

.warning {
  color: var(--danger);
  font-weight: 800;
}

.range-explainer {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 0.75rem;
}

.range-explainer div {
  display: grid;
  gap: 0.35rem;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fbfdff;
  padding: 0.85rem;
}

.range-explainer span {
  color: var(--muted);
  font-size: 0.85rem;
}

.range-explainer b {
  font-size: 1.25rem;
}

@media (max-width: 1120px) {
  .topbar,
  .workspace {
    grid-template-columns: 1fr;
  }

  .safety-banner,
  .utility-panel {
    grid-template-columns: 1fr;
  }

  .result-grid,
  .maintenance-grid,
  .range-explainer,
  .utility-grid {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }

  .guardrail-grid {
    grid-template-columns: 1fr;
  }
}

@media (max-width: 620px) {
  .topbar,
  .workspace {
    width: min(100% - 0.75rem, 1440px);
  }

  .topbar {
    padding-top: 0.85rem;
  }

  .dek {
    font-size: 0.95rem;
  }

  .field-grid,
  .maintenance-grid,
  .result-grid,
  .mode-switch,
  .range-explainer,
  .safety-grid,
  .utility-grid,
  .dose-row {
    grid-template-columns: 1fr;
  }

  .mode-button {
    min-height: auto;
  }

  .section-heading {
    align-items: start;
  }

  .dose-card .section-heading {
    display: grid;
    grid-template-columns: minmax(0, 1fr) auto;
  }

  .dose-card .text-button {
    align-self: end;
    min-width: 5.7rem;
  }

  .dose-row.simple {
    grid-template-columns: 1fr;
  }

  .dose-row .remove-dose {
    width: 3rem;
    height: 2.75rem;
    justify-self: end;
  }

  .metric {
    min-height: 7rem;
  }

  .clinical-note {
    font-size: 0.88rem;
  }

  .input-panel,
  .results-panel,
  .sensitivity-panel,
  .reference-panel {
    padding: 0.7rem;
  }

  .input-with-unit {
    grid-template-columns: minmax(0, 1fr) minmax(3.75rem, auto);
  }

  .input-with-unit span {
    padding: 0 0.55rem;
  }

  input[type="datetime-local"] {
    font-size: 0.95rem;
  }

  .topbar h1 {
    font-size: 1.8rem;
  }

  .help-tip::after {
    left: auto;
    right: -0.5rem;
    transform: translate(0, 0.25rem);
  }

  .help-tip::before {
    left: auto;
    right: 0.05rem;
    transform: translate(0, 0.25rem) rotate(45deg);
  }

  .help-tip:hover::after,
  .help-tip:focus::after {
    transform: translate(0, 0);
  }

  .help-tip:hover::before,
  .help-tip:focus::before {
    transform: translate(0, 0) rotate(45deg);
  }
}